A Greyhound bus and two other vehicles were involved in an accident Thursday night that closed Interstate 70 near Genesee.
The State Patrol said the crash occurred about 7:30 p.m. amid snow-packed conditions and blowing snow.
One lane of westbound I-70 between mile markers 254 and 256 reopened around 10:10 p.m. Troopers said 54 passengers were on the bus, and four people were taken to local hospitals with minor injuries.
The Greyhound passengers were transferred to another bus.
Troopers said the lengthy closure was necessary to remove the wreckage.